Adenosinergic System and Neuroendocrine Syncope: What Is the Link?

Syncope: what is the trigger?

Although a syncopal attack is frequently preceded by prodromal symptoms, sometimes the onset can be so abrupt that there is no warning at all. The switch in autonomic responses responsible for such an attack is quite rapid and dramatic, but the trigger for this remains one of the unresolved mysteries in cardiovascular physiology.

Opiates, sleep, and pain: the adenosinergic link.

BARRING a revolutionary breakthrough in pain management, opiates will remain the mainstay of analgesia for the foreseeable future. For years, researchers chasing the Holy Grail of opiate pharmacology have sought to dissociate their desirable analgesic properties from their undesirable ones. In addition to their well-known respiratory depressant effects and potential for addiction, opiates also ...

P-value: What is and what is not

The misinterpretation and misuse of p-value have been increasing for decades. In March 2016, the American Statistical Association released a statement to warn about the use and interpretation of p-value. In this study, we provided a definition and discussion of p-value and emphasized the importance of its accurate interpretation.    

The adenosinergic system in cancer

High amounts of adenosine are released in the tumor mass. Depending on the levels of adenosine, as well as on the receptor subtypes that are expressed by immune cells, adenosine can affect tumor growth in different fashions. Specifically targeting CD73, the rate-limiting enzyme for the extracellular generation of adenosine, or the A3 receptor offers new therapeutic strategies to limit tumor pro...

Obesity and diabetic retinopathy: What is the association?